Ibrutinib

• Nausea and vomiting
• Diarrhea and/or stomach pain
• Decreased appetite
• Tiredness and lack of energy
• Bone pain or muscle ache
• Mild swelling of the hands or feet
• Skin rash
• Increased risk of bruising or bleeding
  Inform your doctor if you had a recent surgery or if any surgery is planned for you.
• Increased risk of infections
  To minimise risk, avoid crowds or being near people with infection.

Inform your doctor if any of the following occurs:

• Rapid heartbeat, chest discomfort or shortness of breath
• Unusual light-headedness, giddiness or weakness
• Signs of infection – fever of of 38°C or higher, chills, cough, sore throat, pain or difficulty urinating
• Unusual bruising, bleeding or black sticky stools
• Severe diarrhea
• Severe muscle pain or weakness

• Inform your doctor or pharmacist if you:
• Have any other medical conditions e.g. heart problems, liver problems.
• Are taking any other medication or supplements e.g. warfarin, fish oil or vitamin E.
• Use effective birth control during treatment and for 3 months after stopping Ibrutinib. Inform your doctor if you or your partner plan for or suspect pregnancy.

Avoid taking grapefruit and its juice while you are on Ibrutinib.