Ibrutinib

• Nausea and vomiting
• Diarrhea and/or stomach pain
• Decreased appetite
• Tiredness and lack of energy
• Bone pain or muscle ache
• Mild swelling of the hands or feet
• Skin rash
• Increased risk of bruising or bleeding
  Inform your doctor if you had a recent surgery or if any surgery is planned for you.
• Increased risk of infections
  To minimise risk, avoid crowds or being near people with infection.

Inform your doctor if any of the following occurs:

• Rapid heartbeat, chest discomfort or shortness of breath
• Unusual light-headedness, giddiness or weakness
• Signs of infection – fever of of 38°C or higher, chills, cough, sore throat, pain or difficulty urinating
• Unusual bruising, bleeding or black sticky stools
• Severe diarrhea
• Severe muscle pain or weakness

• Inform your doctor or pharmacist if you:
• Have any other medical conditions e.g. heart problems, liver problems.
• Are taking any other medication or supplements e.g. warfarin, fish oil or vitamin E.
• Use effective birth control during treatment and for 3 months after stopping Ibrutinib. Inform your doctor if you or your partner plan for or suspect pregnancy.

Avoid taking grapefruit and its juice while you are on Ibrutinib.

 It is a capsule, taken by mouth once daily and swallowed whole with water. Take at around the same time each day, with or without food. Take the exact number of capsules instructed by your doctor.

If you miss a dose of Ibrutinib, take it as soon as you can on the same day and return to your usual dosing time the next day. Do not double dose to make up for a missed dose.  

If you overdose on this medication, inform your doctor immediately.

Do not chew, open or break the capsule.