Rifampicin

You may notice orange-red discolouration of bodily fluids such as urine, tears and sweat.

• This is a normal reaction by your body to the medication. Do not be alarmed.
• It is also recommended not to wear contact lenses while taking this medication as it can stain the contact lenses.

If you experience any of these symptoms, you should stop your medication and seek immediate medical attention:

• Drug allergy symptoms such as swollen face/eyes/lips/tongue, difficulty in breathing, itchy skin rashes over your whole body
• Signs of liver issues such as dark coloured urine or light coloured stools, nausea and vomiting that does not go away, loss of appetite, stomach pain, yellowing of your eyes or skin
• Fever, chills, feeling tired or weak (flu-like symptoms)
• Unexplained bruising or bleeding

There are some tests that are required to better monitor and manage possible side effects from treatment of tuberculosis. These include:

• Regular blood tests, especially to monitor your liver function

Before starting TB treatment, inform your healthcare professional if:

• You are allergic to this medication or any of the other ingredients of this medication
• You have pre-existing medical conditions such as kidney and/or liver problems, gout
• You consume alcohol regularly
• You intend to become pregnant (conceive) or breastfeed while taking this medication
• You are pregnant or breastfeeding

• If you have active TB, you should stay at home for the first two weeks of your treatment. This is to prevent spreading the bacteria to others, as you are more likely to be able to infect others during this period. If you have close, regular contact with family members or friends, encourage them to visit a doctor to test for TB.
• If you need to leave the house, wear a surgical mask in public spaces and avoid crowded places. Avoid close contact with anyone who may have low immunity (including elderly, young children, pregnant women).
• After taking at least two weeks of effective treatment, you are generally considered non-infectious, meaning less likely to infect others, provided that you continue with the rest of the treatment.
• If you have latent TB, seeing a doctor early and receiving treatment can help to prevent your loved ones from getting active TB in the future.

• Avoid alcohol as it may increase the risk of liver problems.
• Oral contraceptives may not work while you are on Rifampicin. Use a combination of different birth control methods to prevent unplanned pregnancy.
• It is important that you inform your healthcare provider if you are taking other medications – including those for current medical conditions, chronic medications, oral contraceptives (birth control pills), over-the-counter medications, supplements and traditional/herbal remedies – as they may interact with TB medications.

• Do not stop taking your medication without checking with your healthcare professional.
• This medication should be taken at least 30 minutes before food, on an empty stomach. However, if you are having stomach discomfort, you can take them after food instead.
• Take your medication at the same time every day to maintain the same amount of medication in your body.
• In children, an oral liquid formulation (in-house preparation) may be available. Use a medicine spoon or the graduated syringe provided to measure the medication. Do not use household spoons as they may not be accurate.

• If you forget to take a dose, take it as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.
• It is important to complete the entire course of medication, even when you start feeling better during the treatment. This ensures that the tuberculosis bacteria in your body is fully killed.

For the oral liquid formulation, follow the expiry date as stated on the medication label.

​Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.