Bosentan

Common side effects include:

• Flushing, low blood pressure, fainting or headache
• Rise slowly from a sitting or lying position to reduce giddiness when changing position
• Leg swelling (oedema)
• Flu-like symptoms such as nose and throat irritation, stuffy nose or back pain

These side effects may be minimized by starting with a lower dose and may improve or go away with time. Inform your healthcare professional if it becomes bothersome or does not go away.

Rare but serious side effects include:

• Changes in liver function: Signs include dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin.
• Low haemoglobin levels (anaemia): Signs include feeling more tired, weak or shortness of breath.

These side-effects are usually not significant, they are often treatable once detected early. You will need frequent blood tests to monitor for them.

The symptoms of a drug allergy include one or more of the following:

• Swollen face/eyes/lips/tongue
• Difficulty in breathing
• Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Inform your healthcare professional if:

• You are allergic to this medication or any of the other ingredients of this medication.
• You are pregnant, planning to become pregnant, or breastfeeding.
• As this medication may cause birth defects, female patients of childbearing age should take precautions by using at least 2 reliable methods of contraception to avoid pregnancy. If you suspect you may be pregnant, inform your doctor as soon as possible.
• You should not become pregnant for at least 1 month after stopping this medication.
• You have or have had liver or kidney disease.
• You are taking any other medications, including supplements, traditional medications and herbal remedies.

​Avoid taking grapefruit when you are taking this medicine as grapefruit may interact with your medicine and increase the risk of side effects.

Some medications may interact with Bosentan and affect their effectiveness or increase the risk of side effects. However, these medications may also be important for your treatment. Inform your healthcare professional of the other medications you are currently taking. Examples include:

• Glibenclamide/Glyburide, a diabetes medication
• Cyclosporine, a medication for suppression of the immune system
• Medications for bacterial infections (e.g. clarithromycin, erythromycin)
• Medications for fungal infections (e.g. itraconazole, ketoconazole)

Consult your healthcare professional if you are unsure whether your existing medications can be taken together with this medication.