Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) - Causes and Risk Factors

ATTR-CM is caused by a deposition of abnormal misshapen proteins on the heart muscles. This protein, called transthyretin, is normally produced by the liver. Its main function is to transport the thyroid hormone and vitamin A in our bloodstream. Due to either genetic mutation or the ageing process, this transport protein can become misshapen. The abnormal proteins can then be deposited in the heart and various organs, resulting in disease.

There are two types of ATTR-CM:

1) Wild type ATTR-CM

Associated with ageing
Mostly affecting males over 60 years old

2) Hereditary ATTR-CM (hATTR-CM)

Caused by a change or “mutation” in our gene
Is hereditary or passed down from birth
Affects both males and females, with symptoms beginning as early as 50 years old