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Myasthenia Gravis
Myasthenia Gravis - How to prevent?
Myasthenia Gravis - Treatments
How is myasthenia gravis treated?
Intravenous Immune Globulin (IVIG) Treatment
IVIG is derived from donated blood and contains normal antibodies that temporarily counteract the abnormal antibodies in the body.
Plasma Exchange (Plasmapheresis)
Abnormal antibodies are filtered out of the body by a machine, similar to the concept of dialysis.
IVIG or plasmapheresis is used in acute cases.
Medications
Medication such as pyridostigmine is prescribed to improve muscle weakness. Common side effects include increased salivation, diarrhoea and abdominal discomfort.
Immunosuppressant such as steroid is prescribed to suppress the immune system. Side effects include weight gain, water retention, acne, hypertension, diabetes, infections, gastric ulcers, osteoporosis and cataracts. These side effects can be minimised with diet modications and medications.
The above list is not exhaustive and you should discuss these treatment options further with your doctor.
Surgery
In certain instances (e.g. thymoma), removal of the thymus gland is necessary.
With proper treatment, signs and symptoms of MG can be relieved and normal daily function achieved.
Myasthenia Gravis - Preparing for surgery
Myasthenia Gravis - Post-surgery care
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Neurology,
Myasthenia Gravis
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Department of Neurosurgery
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National Neuroscience Institute
The information provided is not intended as medical advice.
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Muscle Nerve 2021 Apr 1.\u003c/li\u003e\u003cli\u003eYihui Goh, Benjamin Yong Qiang Tan, Nicole Ya-Yuan Chong, Margaret Ma, Manjari Lahiri, Andrew Makmur, Yee Cheun Chan, Soon Booon Justin Wong, \u003cstrong\u003eJoy Vijayan\u003c/strong\u003e. D-penicillamine in Wilson\u0027s disease\u0026#58; recognizing the transition from benefit to harm. eNeurologicalSci. 2021 Feb 15; 23\u0026#58;100328.\u003c/li\u003e\u003cli\u003eFaith Huiwen See, Yihui Goh, Ching-Hui Sia, Benjamin Yong-Qiang Tan, Leonard Leong Yeo, \u003cstrong\u003eJoy Vijayan\u003c/strong\u003e, Ahmad Aftab. A Brain-Heart Interaction\u0026#58; Bickerstaff\u0027s brainstem encephalitis with Takotsubo cardiomyopathy. QJM 2020 July 8 doi\u0026#58;10.1093 (Online ahead of print).\u003c/li\u003e\u003cli\u003eSumanth Shivaram, Madhu Nagappa, Ravi Anadurai, BN Nandeesh, Yasha T Chickabasaviah, \u003cstrong\u003eJoy Vijayan\u003c/strong\u003e, Sanjib Sinha, Arun B Taly et al. Vogt-Koyanagi-Harada syndrome- A neurologist\u0027s perspective.\u0026#160; Annals of Indian Academy of Neurology DOI\u0026#58; 10.4103/aian (Online ahead of print)\u003c/li\u003e\u003cli\u003eChong Ya Yuan Nicole, Benjamin Yong-Qiang Tan, \u003cstrong\u003eJoy Vijayan.\u003c/strong\u003e Functional decline in an elderly\u0026#58; Connecting the dots to reach the diagnosis. American Journal of Medicine. 2020; 133(4)\u0026#58; 432-433.\u003c/li\u003e\u003cli\u003eMay MeiQi Liau, Soong Hui Natalie tan, Tan Lixian Chris, \u003cstrong\u003eJoy Vijayan\u003c/strong\u003e, Nisha Suyien Chandran. Facial ulceration in stroke\u0026#58; an usual and lesser known complication described by Wallenberg. Neurology 2017; 90\u0026#58; e1448-e1449.\u003c/li\u003e\u003cli\u003eSundar R, Bandla A, Tan SS, Liao LD, Kumarakulasinghe NB, Jeyasekharan AD, Ow SG, Lim JS, \u003cstrong\u003eVijayan J\u003c/strong\u003e, Therimadasamy AK, Hairom Z, Ang E, Thakor NV, Lee SC, Wilder-Smith EP. Limb hypothermia for preventing Paclitaxwl-induced peripheral neuropathy in breast cancer patients\u0026#58; A pilot study. Front Oncol. 2017 Jan 10;6\u0026#58;274.\u003c/li\u003e\u003cli\u003eChandra B, \u003cstrong\u003eVijayan J\u003c/strong\u003e, Yuki N, Therimadasamy A, Wilder-Smith E. Clinical reasoning\u0026#58; Temporal profile of inflammatory neuropathies\u0026#58; Beginning to make sense of the uncertainties. Neurology 2016 Oct 18;87(16)\u0026#58; e182-e188.\u003c/li\u003e\u003cli\u003eSamarawickrama D, Therimadasamy AK, Chan YC, \u003cstrong\u003eVijayan J\u003c/strong\u003e, Wilder-Smith EP. Nerve ultrasound in electrophysiologically verified Tarsal Tunnel Syndrome. Muscle Nerve 2015 Nov 12.\u003c/li\u003e\u003cli\u003eLeonard LL Yeo, Rahul Rathakrishnan, \u003cstrong\u003eVijayan Joy\u003c/strong\u003e, Aravinda T Kannan, Einar Wilder-Smith. Localizing median neuropathies\u0026#58; the role of different investigations. Annals of Academy of Medicine Singapore 2015; 44\u0026#58; 9.\u003c/li\u003e\u003cli\u003e\u003cstrong\u003eVijayan J\u003c/strong\u003e, Chan YC, Therimadasamy A, Wilder-Smith EP. Role of combined B-mode and Doppler sonography in evaluating neurolymphomatosis. Neurology 2015 Sep 1; 85(9)\u0026#58; 752-5.\u003c/li\u003e\u003cli\u003e\u003cstrong\u003eVijayan J\u003c/strong\u003e, Sharma VK. Neurogenic orthostatic hypotension- management update and role of droxidopa. Ther Clin Risk Manag 2015; 8\u0026#58; 915-23.\u003c/li\u003e\u003cli\u003e\u003cstrong\u003eVijayan, J\u003c/strong\u003e, Sharma VK; Cerebral Venous Thrombosis\u0026#58; A path less travelled and making a difference. Brain Disorders and Therapy; 2014 (accepted for publication)\u003c/li\u003e\u003cli\u003e\u003cstrong\u003eJoy Vijayan\u003c/strong\u003e, Chuen YC, Punzalan AM, Wilder-Smith EP. A 27-year old man with hand numbness\u0026#58; Exploring new horizons and reinventing the past. Neurology 2014 March11; 82(10)\u0026#58;e80-4.\u0026#160;\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"22\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003e\u003cstrong\u003eJoy Vijayan\u003c/strong\u003e, Therimadasamy AK, Chan YC, Wilder-Smith EP. Combined Doppler and B-mode sonography in Carpal Tunnel Syndrome. J Neurological Sciences 2011 Sept 15;308(1-2)\u0026#58; 16-20.3.\u0026#160;\u0026#160;\u0026#160; \u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"23\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003eEsther ST Ng, \u003cstrong\u003eJoy Vijayan\u003c/strong\u003e, AK Therimadasamy, TC Tan, YC Chan, A Lim, EW Smith. The added value of Pre-operative ultrasonography of the ulnar nerve\u0026#58; an observational study. Muscle and Nerve 2010; 42 (4)\u0026#58; 613-614.\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"24\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003e\u003cstrong\u003eJ Vijayan\u003c/strong\u003e, MLS Tai, A Ahmad, VK Sharma. An unhappy patient following successful sonothrombolysis in Vertebrobasilar thrombosis\u0026#58; Dilemma with final diagnosis. Journal of Neuroimaging 2011; 21 (2)\u0026#58; e173-e176.\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"25\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003eES Ng, \u003cstrong\u003eJ Vijayan\u003c/strong\u003e, AK Therimadasamy, TC Tan, YC Chan, A Lim, E Wilder-Smith. High resolution ultrasonography in the diagnosis of ulnar nerve lesions with particular reference to post-traumatic lesions and sites outside the elbow. Clinical Neurophysiology 2011; 122(1)\u0026#58; 188-93.\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"26\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003eDK Prashantha, AB Taly, S Sinha, TC Yasha, N Gayathri, JME Kovur, \u003cstrong\u003eJ Vijayan\u003c/strong\u003e. Familial amyloidotic polyneuropathy with muscle wasting, vitreous, leptomeningeal and cardiac involvement\u0026#58; Phenotypic, pathological and MRI description. Ann Indian Academy of Neurology 2010; 13(2) 142-144.\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"27\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003e\u003cstrong\u003eVijayan J\u003c/strong\u003e, NG ST, Therimadasamy AK, Titus L, Wilder-Smith EP. A 54 year women with hand dysesthesia\u0026#58; many dimensions to a common problem. Neurology 2009; 73\u0026#58; e68-e72.\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"28\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003e\u003cstrong\u003eVijayan J\u003c/strong\u003e, Therimadasamy AK, Teoh HL, Chan YC, Wilder-Smith EP. Sonography as an aid in diagnosing Tarsal tunnel syndrome. Am J Phy Med Rehab. 2009 Jun; 88(6)\u0026#58; 500-1.\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"29\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003e\u003cstrong\u003eVijayan J\u003c/strong\u003e, Therimadasamy AK, Chan C, Wilder-Smith EP. Diagnostic utility of ultrasound in Posterior Interosseous Nerve Syndrome. Archives of Neurology 2009; 66(7)\u0026#58; 902-903.\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"30\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003eC Shyambabu, S Sinha, AB Taly, \u003cstrong\u003eJ Vijayan\u003c/strong\u003e, JME Kovoor. Serum B12 deficiency and hyperhomocysteinemia\u0026#58; A reversible cause of acute chorea, cerebellar ataxia in an adult with cerebral ischaemia. J Neurological Sciences 2008; 273\u0026#58; 152-154.\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"31\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003eMani RS, Yasha TC, Nagarathna S, Chandramukhi A, Shivprakash MR, \u003cstrong\u003eVijayan J\u003c/strong\u003e, Prasantha DK, Pillai SV, Natarajan A, Kovoor J. Cerebral phaeohyphomycosis caused by Scytalidium dimidiatum\u0026#58; a case report from India. Medical Mycology 2008; 46\u0026#58; 705-711.\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"32\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003e\u003cstrong\u003eJ Vijayan\u003c/strong\u003e, S Sinha, S Ravishankar, AB Taly. MR imaging in multiple system atrophy\u0026#58; Its role in \u0026quot;splitting\u0026#58; Parkinsonism. Ann Indian Academy of Neurology 2008; 11(4)\u0026#58; 257-258.\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"33\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003eKarkare K, Sinha S, Ravishankar S, Gayathri N, Yasha TC, Goyal MK, \u003cstrong\u003eVijayan J\u003c/strong\u003e, Vannirajan A, Thangaraj K, Taly AB. Epilepsia partialis continua in mitochondrial dysfunction\u0026#58; Interesting phenotypic and MRI Observations. Ann Indian Academy of Neurology 2008; 11\u0026#58; 193-96\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"34\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003ePraveen Kumar S, Sinha S, Taly AB, Jayasree S, Ravi V, \u003cstrong\u003eVijayan J\u003c/strong\u003e, Ravishankar. Electroencephalographic and imaging profile in a subacute sclerosing panencephalitis (SSPE) cohort\u0026#58; a correlative study. Clin Neurophysiol. 2007; 118(9)\u0026#58; 1947-54.\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"35\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003eKarkare K, Sinha S, Ravishankar S, Gayathri N, Yasha TC, Goyal MK, \u003cstrong\u003eVijayan J\u003c/strong\u003e, Vannirajan A, Thangaraj K, Taly AB. Epilepsia partialis continua in mitochondrial dysfunction\u0026#58; Interesting phenotypic and MRI Observations. Ann Indian Academy of Neurology 2008; 11\u0026#58; 193-96.\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"36\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003ePraveen KS, Sinha S, Chandrasekhar HS, \u003cstrong\u003eVijayan J\u003c/strong\u003e, Taly AB. Sporadic onset Creutzfeldt-Jacob disease\u0026#58; Interesting MRI observations. Neurology India 2006; 54(4)\u0026#58; 418-420\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"37\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003eKumar S, \u003cstrong\u003eVijayan J\u003c/strong\u003e, Jacob J, Aaron S, Joseph M, Alexander M, Gnanamuthu C. Cervical spine injuries in 64 attempted suicidal hangings in India. Tropical Doctor 2005; 35(4)\u0026#58; 198-200.\u003cbr\u003e\u003c/li\u003e\u003c/ol\u003e\u003col start=\"38\" style=\"list-style-type\u0026#58;decimal;\"\u003e\u003cli\u003eS Aaron, S Kumar\u003cstrong\u003e, J Vijayan\u003c/strong\u003e, J Jacob, M Alexander, C Gnanamuthu. Clinical and laboratory features and response to treatment in patients presenting with Vitamin B12 deficiency related neurological syndromes. 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