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Clin Asst Prof Lin Xuling

MBBS, MRCP (United Kingdom)

Research Interest:

Brain tumor clinical trials
Cancer genomics
Neuroimaging

Clinical Appointments

Senior Consultant Department of Neurology National Neuroscience Institute
Visiting Consultant Division of Medical Oncology National Cancer Centre Singapore
Assistant Director, Research (Research Platforms) Research (National Neuroscience Institute) National Neuroscience Institute

Profile

Clin Asst Prof Lin Xuling is a Neurologist, sub-specialised in Neuro-Oncology. She was awarded the SingHealth HMDP Award in 2014 and received a two-year Neuro-Oncology fellowship training at Memorial Sloan Kettering Cancer Center in New York. She has since resumed work at the National Neuroscience Institute in Singapore and manage patients with Neurology and Neuro-Oncology conditions.

Clin Asst Prof Lin is passionate about clinical research. During her advanced specialist (residency) and fellowship training, she participated actively in the design and running of several clinical studies. Her research interests range from neurocognition and neuroimaging to cancer genomics and brain tumour clinical trials.

Professional Appointments and Committee Memberships

Senior Consultant, Department of Neurology, National Neuroscience Institute, 2021 - Present
Assistant Director, Research (Research Platforms), National Neuroscience Institute, 2021 - Present
Consultant, Department of Neurology, National Neuroscience Institute, 2016 - 2021
Associate Consultant, Department of Neurology, National Neuroscience Institute, 2014 - 2016
Visiting Consultant, Medical Oncology, National Cancer Centre, 2017 - Present
Visiting Consultant, Medical Oncology, Tan Tock Seng Hospital
Programme Director, NNI Brain Tumours Clinical Programme, 2018 - Present
Clinical Assistant Professor, Duke-National University of Singapore
Clinical Lecturer, Yong Loo Lin School of Medicine
Clinical Teacher, Lee Kong Chian School of Medicine
Member, Personalised Medicine Clinical Genomics Work Group, Tan Tock Seng Hospital, 2017 - Present
Member, Cancer Service Line Development, National Cancer Centre, Singapore 2017 - Present
Fellow, Neuro-Oncology, Memorial Sloan Kettering Cancer Center, 2014 - 2016

Education

MMED Internal Medicine (Singapore), 2011
MRCP (United Kingdom, 2010
MBBS National University of Singapore, 2007

Awards

Best Registrar Award, SingHealth Residency, 2014
SingHealth HMDP Award, FY2014 Fellowship in Neuro-Oncology, 2014

Research Studies

A Randomized, Placebo Controlled Phase 2b/3 Study of ABT-414 with Concurrent Chemoradiation and Adjuvant Temozolomide In Subjects with Newly Diagnosed Glioblastoma (GBM) with Epidermal Growth Factor Receptor (EGFR) Amplification (Intellance1) (NCT02573324), Co-Investigator 2017-present
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to evaluate the efficacy and safety, of SA237 as Monotherapy in patients with Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD) (NCT02073279), Co-Investigator 2016-present
A Proof-of-Concept, Pilot Study of Pembrolizumab (MK-3475) in Patients with Recurrent Malignant Glioma with a Hypermutator Phenotype (NCT02658279), Investigator 2016-present

Publications

X Lin, M Fleisher, M Rosenblum, O Lin, A Boire, S Briggs, Y Bensman, B Hurtado, L Shagabayeva, L DeAngelis, K Panageas, A Omuro, E Pentsova. Cerebrospinal Fluid Circulating Tumor Cells: A Novel Tool to Diagnose Leptomeningeal Metastases from Epithelial Tumors. Neuro Oncol 2017;19(9):1248-54
X Lin, M Lee, O Buck, KM Woo, Z Zhang, V Hatzoglou, A Omuro, J Arevalo-Perez, AA Thomas, J Huse, K Peck, AI Holodny, RJ Young. Diagnostic Accuracy of T1-Weighted DCE-MRI and DWI-ADC for Differentiation of Glioblastoma and Primary CNS Lymphoma. AJNR Am J Neuroradiol 2017;38(3):485-91
X Lin, WY Yu, L Liauw, RJ Chander, WE Soon, WY Lee, K Tan. Clinicoradiological Features Distinguish Tumefactive Multiple Sclerosis from CNS Neoplasms. Neurol Clin Pract 2017;7:1-12
PS Sachdev, JW Lo, JD Crawford, L Mellon, A Hickey, D Williams, R Bordet, AM Mendyk, P Gelé, D Deplanque, HJ Bae, JS Lim, A Brodtmann, E Werden, T Cumming, S Köhler, FR Verhey, YH Dong, HH Tan, C Chen, X Xin, RN Kalaria, LM Allan, RO Akinyemi, A Ogunniyi, A Klimkowicz-Mrowiec, M Dichgans, FA Wollenweber, V Zietemann, M Hoffmann, DW Desmond, T Linden, C Blomstrand, B Fagerberg, I Skoog, O Godefroy, M Barbay, M Roussel, BC Lee, KH Yu, J Wardlaw, SJ Makin, FN Doubal, FM Chappell, VK Srikanth, AG Thrift, GA Donnan, N Kandiah, RJ Chander, X Lin, C Cordonnier, S Moulin, C Rossi, B Sabayan, DJ Stott, JW Jukema, S Melkas, H Jokinen, T Erkinjuntti, VC Mok, A Wong, BY Lam, D Leys, H Hénon, S Bombois, DM Lipnicki, NA Kochan; STROKOG. STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease. Alzheimers Dement (Amst) 2016;18;7:11-23
X Lin, M Daras, E Pentsova, CP Nolan, IT Gavrilovic, LM DeAngelis, TJ Kaley. Bevacizumab in high grade glioma (HGG) patients following intraparenchymal hemorrhage (IPH). Neuro Oncol Pract 2016;0:1-5
EI Pentsova, RH Shah, J Tang, A Boire, D You, S Briggs, A Omuro, X Lin, M Fleisher, C Grommes, KS Panageas, F Meng, SD Selcuku, S Ogilvie, N Distefano, L Shagabayeva, M Rosenblum, L DeAngelis, A Viale, IK Mellinghoff, MF Berger. Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid. J Clin Oncol. 2016;34(20):2404-2415.
N Kandiah, RJ Chander, X Lin, A Ng, YY Poh, CY Cheong, AR Cenina, PN Assam. Cognitive Impariment after Mild Stroke: Development and Validation of the SIGNAL2 Risk Score. J Alzheimers Dis. 2016;49:1169-77
N Kandiah, V Wang, X Lin, NN Nyu, L Lim, S Hameed, HL Wee. Cost Related to Dementia in the Young and the Impact of Etiological Subtype on Cost. J Alzheimers Dis. 2016;49:227-85
X Lin, L DeAngelis. Treatment of Brain Metastases. J Clin Oncol. 2015;33(30):3475-84
The Singapore Cancer Network (SCAN) Neuro-Oncology Workgroup. Singapore Cancer Network (SCAN) Guidelines for Systemic Therapy of High-Grade Glioma. Ann Acad Med Singapore 2015;44:463-73
X Lin, WY Yu, G Priego, N CK Tan. Nodular nerves and lumpy leptomeninges – neuroimaging in primary leptomeningeal lymphoma. Neurol Asia 2014;19(4):421-3
X Lin, KE Lee. Numb Cheek Syndrome: A Clinical-Anatomical Correlation. Eur Neurol 2013;70:331-2
CJ Renaud, X Lin, S Subramanian, DA Fisher. High-dose cefazolin on consecutive hemodialysis in anuric patients with Staphylococcal bacteraemia. Hemodial Int. 2011;15:63-8