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Prof Lim Kah Leong

Ph.D

Visiting Lead (Strategic Alliances)

Research (National Neuroscience Institute)

National Neuroscience Institute

Research Interest:

Parkinson Disease & Neurodegenerative Diseases

Research Appointments

Visiting Lead (Strategic Alliances) Research (National Neuroscience Institute) Research (National Neuroscience Institute)

Profile

Prof Lim Kah Leong is Visiting Lead (Strategic Alliances) at the National Neuroscience Institute.

Professional Appointments and Committee Memberships

Head, Department of Physiology, National University of Singapore, 2018 - Present
Visiting Lead (Strategic Alliances), National Neuroscience Institute (20% FTE), 2018 - Present
Visiting Professor, Northwestern Polytechnical University, China, 2018 - Present
Visiting Professor, Nanjing Tech University, China, 2015 - Present
Chair, LSI Neurobiology and Ageing Programme Steering Committee, National University of Singapore* (*Acting Head when Programme Leader is away), 2012 - Present
Faculty, NUS Graduate School for Integrative Sciences & Engineering, 2011 - Present
Associate Professor (Honorary Regular Rank), Duke-NUS Medical School, 2009 - Present

Education

Ph.D. (Molecular and Cell Biology), Institute of Molecular and Cell Biology, Singapore, 1993-1999
B.Sc. Honors (Cell and Molecular Biology), National University of Singapore, 1992-1993
B.Sc., National University of Singapore, 1989-1992

Awards

President Science Award (Team), 2018
Singapore Neuroscience Association Distinguished Neuroscientist Award, 2018
CeLS Safety Award (GOLD) for outstanding laboratory safety performance, 2017
GCEO Outstanding Administrator Award, 2016
SingHealth Excellence Award (Distinguished Team Award), 2015
Profile featured in ALUMNUS (Alumni Magazine of NUS) under the cover story “The making of a research university”, 2013
Khoo Discovery Award, Duke-NUS Graduate Medical School, 2008
Outstanding Mentor Award, Science Mentorship Program, Ministry Of Education, 2008
Poster Award (Corresponding Author), Gordon Research Conference on Autophagy in stress, development and disease, CA, USA, 2008
First IMCB alumnus to be featured on IMCB News Website (April 1st 2008) under the series entitled “Where are they now?”, 2008
Merit Award (Poster), 4th Combined Scientific Meeting. NUS, 2003
National Science Scholarship International Fellowship, A*STAR, 2002

Research Studies

Publications

Hang, L.T., Thundyil, J., Lim, K.L. AMPK-PGC1-alpha Axis is selectively disrupted in the Ventral Midbrain of Parkin-deficient mice Neuromolecular Medicine 21(1):25-32 (2019)
Ci, Q., Zhang, S.Y., Qin, X., Liu, J., Han, L., Li, H., Lim, K.L., Zhang, C.W., Li, L., Huang, W. Polydopamine Dots-Based Fluorescent Nanoswitch Assay for Reversible Recognition of Glutamic Acid and Al3+ in Human Serum and Living Cell ACS Applied Materials and Interface 10(42):35760-35769 (2018) (IF: 8.097)
Liu, C., Zhang, C.W., Ang, S.T., Lo, S.Q., Chew, K.C.M., Yu, D., Chai, B., Tan, B., Tsang, F., Tai, Y.K., Liang, M.C., Tan, H.T., Lai, M.K.P., Chung, M.C., Khanna, S., Lim, K.L., Soong, T.W. S-nitrosylation of divalent metal transporter 1 enhances iron uptake to mediate loss of dopaminergic neurons and motoric deficit
Journal of Neuroscience 38(39):8364-8377 (2018)
Serra, A., Gallart-Palau, X., Park, J.E., Lim, G.G., Lim, K.L., Ho, H.W., Tam, J.P, Sze, K.S. Vascular bed molecular profiling by differential systemic decelullarization in vivo (DISDIVO) Arteriosclerosis, Thrombosis, and Vascular Biology 38(10):2396-2409 (2018)
Ding, Y., Xin, C., Zhang, C.W., Lim, K.L., Zhang, H., Fu, Z., Li, L., Huang, W. Natural molecules from Chinese Herbs protecting against Parkinson’s disease via anti-oxidative stress Frontiers in Aging Neuroscience Aug 28;10:246 (2018)
Weng, M.R., Xie, X., Liu, C., Lim, K.L., Zhang, C.W., Li, L. The Sources of Reactive Oxygen Species and their possible role in the pathogenesis of Parkinson’s Disease Parkinson’s disease Sep 2; 2018:9163040 (2018)
Wang, L., Tang, Y., Shi, Y., Deng, S., Lu, G., Zhang, J., Yi, R., Wang, C., Bay, B.H., Lim, K.L., Liou, Y.C., Youle, R., Yap, C., Shen, H.M. PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy Cell Research 28(8):872-873 (2018)
Tan, K.K.B, Lim, W.M., Chai, C., Kukumberg, M., Lim, K.L., Goh, E.L.K, Yim, E.K.F. Sequential Application of Discrete Topographical Patterns Enhances Derivation of Functional Mesencephalic Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Scientific Reports 8 (1): 9567 (2018)
Baek, J., Tee, J.K., Pang, Y.Y., Tan, E.Y., Lim, K.L., Ho, H.K., Loo, S.C.J.Improved Bioavailability of Levodopa using Floatable Spray Coated-Microcapsules for the Management of Parkinson’s DiseaseNeuromolecular Medicine 20 (2): 262-270 (2018)
Shao, Y., Ma, X., Paira, P., Tan, A., Herr, D.R., Lim, K.L., Ng, C.H., Venkatesan, G., Klotz, K., Federico, S., Spalluto, G., Cheong, S.L., Chen, Y.Z., Pastorin, G.Discovery of indolylpiperazinylpyrimidines with 1 dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson’s disease treatmentPLoS One 13 (1):e0188212 (2018)
Liu, C.*, Zhang, C.W.*, Zhou, Y, Wong, W.Q. Stanton L., Lim, K.L., Xiao, Z.C., Dawe, G.APP up-regulates JNK3 expression and contributes to retinal ganglion cell degeneration after optic nerve axotomyCell Death and Differentiation 25 (4): 661-676 (2018)
Xiao, B., Goh, J.Y., Xiao, L., Lim, K.L., Liou, Y.C.ROS trigger Parkin/PINK1-dependent mitophagy by inducing mitochondrial recruitment of ParkinJournal of Biological Chemistry 292(40):16697-1670 (2017)
Basil., A.H., Sim, J.P.L., Lim, G.G., Lin, S.P., Engelender, S., Lim, K.L.Overexpression of AF-6 protects against dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson’s diseaseFrontiers in Cellular Neuroscience 11: 241 (2017)
Xiao, B., Deng, X., Lim, G.G., Xie, S., Zhou, Z.D., Lim, K.L., Tan, E.K.Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondriaCell Death and Disease 8(10):e3097 (2017)
Zhang, C.W., Tai, Y.K., Chai, B.H., Chew, K.C.M., Ang, E.T., Fai, T., Tan, B.W.Q., Hong, E.T.E., Abu Bakar, A., Chuang, K.H., Lim, K.L.*, Soong, T.W.* (*co-corresponding)Transgenic Mice Overexpressing the Divalent Metal Transporter 1 Exhibit Iron Accumulation and Enhanced Parkin Expression in the BrainNeuromolecular Medicine 19 (2-3): 375-386 (2017)
Ng, C.H., Hang, L.T., Lim, K.L.Mitochondrial homeostasis in Parkinson’s disease- a triumvirate rules?Neural Regeneration Research 12(8):1270-1272 (2017)
Chen, Z.C., Zhang, W., Chua, L.L., Li, R., Lin, L., Zhen, C., Angeles, D., Stanton, L, Peng, J., Lim, K.L., Zeng, L., Tan, E.K.Lrrk2 mutations increase APP phosphorylation and promote APP intracellular domain to induce neurotoxicity in Parkinson’s diseaseScience Signaling 10(488). pii: eaam6790 (2017)
Prasad, A., Teh, D.B.T., Blasiak, A., Chai, C., Wu, Y., Gharibani, P.M., Yang, I.H., Phan, T.T., Lim, K.L., Yang, H., Liu, X., All, A.H. Static Magnetic Field Stimulation Enhances Oligodendrocyte Differentiation and Secretion of Neurotrophic Factors. Scientific Reports 7 (1): 6743 (2017)
Lim, G.G. and Lim, K.L. Parkin-independent Mitophagy – FKBP8 takes the stage EMBO Reports 18: 864-5 (2017)
Ng, C.H., Basil, A.H., Hang, L.T., Tan, R., O’Neill S., Zhang, X.D., Yu, F., Lim, K.L. Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson’s disease Neurobiology of Aging 55: 33-37 (2017)