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Assoc Prof Kirollos Ramez Wadie

M.B.Ch.B (Honours), Doctor of Medicine (Leeds), F.R.C.S. (Ed.), F.R.C.S.(Eng.), F.R.C.S. (Neurosurgery), Fellow of the European Board in Neurosurgery (FEBNS)

Senior Consultant

National Neuroscience Institute

Specialty: Neurosurgery, Surgery ＆ Surgical Oncology

Clinical Interest: Skull Base Surgery, Cerebrovascular Surgery, Neurosurgery

Conditions Treated by this Doctor:
Arteriovenous Malformation (AVM), Brain Aneurysm, Intracranial Aneurysms, Intracranial Meningiomas, Intraventricular Tumours, Microvascular Decompression, Pineal Tumours, Pituitary Lesions, Skull Base Surgery.

Clinical Appointments

Senior Consultant Department of Neurosurgery National Neuroscience Institute
Senior Consultant Neurosurgery Singapore General Hospital
Senior Consultant Division of Surgery ＆ Surgical Oncology National Cancer Centre Singapore

Profile

Dr Ramez Wadie Kirollos graduated from the Medical School at the University of Alexandria in Egypt in 1984. In 1987, he moved to the United Kingdom to pursue his post-graduate medical education. He received the prestigious Royal College of Surgeons of England Hallett Prize given to the candidate with the highest score at the fellowship examination (FRCS Eng). Dr Kirollos trained in neurosurgery at the Atkinson Morley Hospital in London, the Frenchay Hospital in Bristol, the Leeds General Infirmary, and the Walton Centre for Neurology and Neurosurgery in Liverpool. He obtained an MD (Doctor of Medicine) degree for his research into photodynamic therapy of pituitary adenomas. Dr Kirollos completed a skull base fellowship under Dr Gentili at the Toronto Western Hospital.

In 2001, he was appointed Consultant Neurosurgeon at the Addenbrooke’s Cambridge University Hospital and associate lecturer in Cambridge University clinical school until June 2018. His main clinical interests include skull base, pituitary and pineal surgery, and surgical treatment of AVMs. He has performed over 670 aneurysm operations. He was in the past the President of the British Neurovascular Group, President and co-founder of the British-Irish Meningioma Society, member of the postgraduate educational committee of the EANS, ex officio member of the SBNS council as representative for the SBNS to the EANS and WFNS and currently is a member of the neuro-oncology committee of the WFNS. Dr Kirollos has over 75 publications, 100 presentations, 30 invited lectures and written few chapters and a book and is the co-editor of the Oxford Textbook of Neurosurgery.

Dr Kirollos has been actively involved in day-to-day teaching of medical students, junior and middle grade neurosurgical trainees. Dr Kirollos co-founded and directed the Cambridge lectures in Neurosurgical Anatomy in 2005 and the British Neurosurgical Trainee Courses in 2010 and serves as a faculty on the Neuroanatomy of Operative Approaches since its conception in 2005 and numerous national and international courses. In 2006 Dr Kirollos was elected as a member of the Court of Examiners of the Royal College of Surgeons of England. For his commitment to surgical education he received the prestigious Silver Scalpel Award in 2010.

Education

M.B.Ch.B (Honours)

Doctor of Medicine (Leeds)

F.R.C.S. (Ed.)

F.R.C.S.(Eng.)

F.R.C.S. (Neurosurgery)

Fellow of the European Board in Neurosurgery (FEBNS)

Professional Appointments and Committee Memberships

Member of Court of Examiners, Examiner Royal College of Surgeons of England, Commenced 2006
President (2016/2017) & Past President (2017/2018) of the British – Irish Meningioma Society (BIMS), Co-founder, From 2016
Member of the Neuro-oncology Committee of the World Federation of Neurosurgery (WFNS), From 2018
Director of the Cambridge Lectures in Neurosurgical Anatomy (CLNA), Co-founder, Established in 2005
Convener and co-founder of the British Neurosurgical Training Course (BNTC), Established 2010

Awards

The Hallett Prize 1986
The Silver Scalpel Award 2010

Research Interests

Publications

Headache after dural puncture. Whitely SM, Murphy PG, Kirollos RW, Swindells SR. British Medical Journal. 306: 917-918, April 1993.
Adult respiratory distress syndrome following attempted strangulation. Murphy PG, Jackson R, Kirollos R, Gibson JS, Chennells P. British Journal of Anaesthesia. 70: 583-586, 1993.
Post-traumatic cerebellar infarction. Tyagi AK, Kirollos RW, Marks PV. British Journal of Neurosurgery. 9 (5): 683-686, 1995.
Cerebellar mutism following posterior fossa tumour surgery. Jones S, Kirollos R, van Hille P. British Journal of Neurosurgery. 10 (2): 221-224, 1996.
An unusual case of spinal metastasis from a liposarcoma. Kirollos R, Koutsoubelis G, Ross S, Al Sarraj S. European Journal of Surgical Oncology. 22 (3): 303-305, 1996.
Evaluation of surgery for the tethered cord syndrome using a new grading system. Kirollos RW, van Hille PT. British Journal of Neurosurgery. 10 (3): 253-260, 1996.
Tuberculous osteitis of the skull: a case report and review of the literature. Tyagi AK, Kirollos RW, Kang NV. British Journal of Neurosurgery. 10 (4): 399-401, 1996.
Endoscopy-assisted burr hole evacuation of subdural empyema. Kirollos RW, Tyagi AK, Boles DM. British Journal of Neurosurgery. 10 (4): 395-397, 1996.
Value of early post-operative plain radiography following B.O.P. fusion in cervical spinal surgery. Millares-Martin P, Ross S, Kirollos R. British Journal of Neurosurgery. 11 (4): 344-345, 1997.
Muslin-induced granuloma following wrapping of intracranial aneurysms - The role of infection as an additional pathology. Kirollos RW, Tyagi AK, Marks PV, van Hille PT. Acta Neurochirurgica. 139 (5): 411-415, 1997.
A preliminary experimental in vivo study of the effect of Photodynamic Therapy on human pituitary adenoma implanted in mice. Kirollos RW, Marks PV, Igbaseimokumo U, Chakrabarty A. British Journal of Neurosurgery. 12 (2): 140-145, 1998.
The value of MR imaging in differentiating between hard and soft cervical disc disease: a comparison with intraoperative findings. Sengupta DK, Kirollos R, Findlay GF, Smith ET, Pearson JCG, Pigott T. European Spine Journal. 8 (3): 199-204, 1999.
Primary intradural classic chondrosarcoma: case report and literature review. Bosma JJD, Kirollos RW, Broome J, Eldridge PR. Neurosurgery. 48 (2): 420-423, 2001.
Management of spontaneous cerebellar haematomas: a prospective treatment protocol. Kirollos RW, Tyagi AK, Ross SA, van Hille PT, Marks PV. Neurosurgery. 49 (6): 1378-1386, 2001.
Endoscopic treatment of suprasellar and third ventricle-related arachnoid cysts. Kirollos RW, Javadpour M, May P, Mallucci C. Child’s Nervous System. 17 (12): 713-718, 2001.
A 5-year study of the outcome of surgically treated depressed skull fractures. Al-Haddad SA, Kirollos R. Annals of the Royal College of Surgeons of England. 84 (3): 196-200, 2002.
Endovascularly treated cerebral aneurysm using Guglielmi detachable coils acting as a nidus for brain abscess formation secondary to Salmonella bacteremia: case report. Kirollos RW, Bosma JJ, Radhakrishnan J, Pigott TD. Neurosurgery. 51 (1): 234-237, 2002.
Spontaneous pneumocephalus. Santarius T, Antoun NM, Kirollos RW. British Medical Journal, Minerva. 325: 554, 2002.
Lessons to be learnt from the International subarachnoid Haemorrhage Trial (ISAT). Kirkpatrick PJ, Kirollos RW, Higgins N, Matta B. British Journal of Neurosurgery. 17 (1): 5-7, 2003.
Detection and evaluation of intracranial aneurysms with 16-row multislice CT angiography. Tipper G, U-King-Im JM, Price SJ, Trivedi RA, Cross JJ, Higgins NJ, Farmer R, Wat J, Kirollos R, Kirkpatrick PJ, Antoun NM, Gillard JH. Clinical Radiology. 60 (5): 565-572, 2005.
Ruptured Berry Aneurysms: clip or coil? Marcus H, Kirollos R. The Internet Journal of Neurosurgery. 3 (2), 2006.
Sporadic malignant nerve sheath tumour of the occulomotor nerve. Santarius T, Chia HL, Xuereb JH, Kirollos RW. Acta neurochurigica (Wien). 149 (6): 617-622, 2007.
Tumefactive demyelinating lesion. Guilfoyle MR, Kirollos RW. Neurology. 68 (24): 2155, 2007.
Papillary tumour of the pineal region. Santarius T, Joseph JA, Tsang KT, O’Donovan DG, Kirollos RW. British Journal of Neurosurgery. 22(1): 116-120, 2008.
Impact of brain biopsy on the management of patients with nonneoplastic undiagnosed neurological disorders. Pulhorn H, Quigley DG, Bosma JJ, Kirollos R, DU Plessis DG, Jenkinson MD. Neurosurgery. 62(4): 833-837, 2008.
A Second Biopsy? – Tandem Lesion. Ganesan D, Dean Af, Antoun N, Kirollos RW. Acta Neurochirurgica (Wien). 150(5): 501-503, 2008.
Radiotherapy as as adjuvant in the management of intracranial meningiomas: are we practicing evidence-based medicine? Marcus HJ, Price SJ, Wilby M, Santarius T, Kirollos RW. British Journal of Neurosuregry. 22(4): 520-8, 2008 Aug. Review.
Transient Broca’s Apasia as feature of an extradural abscess. Commondoor R, Eisenhut M, Fowler C, Kirollos RW, Nathwani N. Pediatr Neurol. 40(1): 50-3, 2009 Jan.
Paraganglioma of cauda equine. Iliadis C, Kirgiannis K, Wozniak G, Vlychou M, Santarius T, Kirollos RW. Neurol Neurochir Pol. 42(5): 463-466, 2008 September-October.
Considerations in the Management of Cerebral Arterio-Venous Malformations. Trivedi R, Kirollos R, Whitfield P. ACNR July/August 2009; 9(3): 26-29.
Intracranial Arteriovenous Malformations. Weerakkody RA, Trivedi R, Santarius T, Kirollos RW. British Journal of Neurosuregry. 21:1-5. 2009 Aug.
Use of drains versus no drains after burr-hole evacuation of chronic subdural haematoma: a randomised controlled trial. Santarius T, Kirkpatrick PJ, Ganesan D, Chia HL, Jalloh I, Smielewski P, Richards HK, Marcus H, Parker RA, Price SJ, Kirollos RW, Pickard JD, Hutchinson PJ. Lancet. 2009 Sep 26;374(9695):1067-73.
Management of arteriovenous malformations (AVMs) presenting with intracranial haemorrhage: the role of subacute resection. Marcus H, Weerakkody RA, Trivedi R, Santarius T, Kirollos R. British Journal of Neurosuregry. 2010 Feb;24(1):95.
The role of external drains and peritoneal conduits in the treatment of recurrent chronic subdural hematoma. Santarius T, Qureshi HU, Sivakumaran R, Kirkpatrick PJ, Kirollos RW, Hutchinson PJ. World Neurosurg. 2010 Jun;73(6):747-50.
Causes of neurological deficits following of clipping 200 consecutive ruptured aneurysms in patients with good-grade aneurysmal subarachnoid hemorrhage. Bulters DO, Santarius T, Chia HL, Parker RA, Trivedi R, Kirkpatrick PJ, Kirollos RW. Acta neurochurigica (Wien). 2011 Feb; 153(2):295-303.
Intra-abdominal metastasis of an intracranial germinoma via ventriculo-peritoneal shunt in a 13-year-old female. Murray MJ, Metayer LE, Mallucci CL, Hale JP, Nicholson JC, Kirollos RW, Burke GA. British Journal of Neurosurgery. 2011 Dec;25(6):747-9.
Temozolomide responsiveness in aggressive corticotroph tumours: a case report and review of the literature. Annamalai AK, Dean AF, Kandasamy N, Kovacs K, Burton H, Halsall DJ, Shaw AS, Antoun NM, Cheow HK, Kirollos RW, Pickard JD, Simpson HL, Jefferies SJ, Burnet NG, Gurnell M. Pituitary. 2012 Sep;15(3):276-87.
A mathematical model of utility for single screening of asymptomatic unruptured intracranial aneurysms at the age of 50 years. Li LM, Bulters DO, Kirollos RW. Acta Neurochir (Wien). 2012 Jul;154(7):1145-52. 39. Bochdalek's flower basket: applied neuroimaging morphometry and variants of choroid plexus in the cerebellopontine angles. Horsburgh A, Kirollos RW, Massoud TF. Neuroradiology. 2012 Dec;54(12):1341-6.
How I do it-pineal surgery: supracerebellar infratentorial versus occipital transtentorial. Hart MG, Santarius T, Kirollos RW. Acta Neurochir (Wien). 2013 Mar;155(3):463-7.
Role of surgery, radiotherapy and chemotherapy in papillary tumors of the pineal region: a multicenter study. Fauchon F, Hasselblatt M, Jouvet A, Champier J, Popovic M, Kirollos R, Santarius T, Amemiya S, Kumabe T, Frappaz D, Lonjon M, Fèvre Montange M, Vasiljevic A. J Neurooncol. 2013 Apr;112(2):223-31.
Ophthalmological outcome after resection of tumors based on the pineal gland. Hart MG, Sarkies NJ, Santarius T, Kirollos RW. J Neurosurg. 2013 Aug;119(2):420-6.
Tuber Cinereum Proximity to Critical Major Arteries: A Morphometric Imaging Analysis Relevant to Endoscopic Third Ventriculostomy. Horsburgh A, Matys T, Kirollos RW, Massoud TF. Acta Neurochir (Wien). 2013 May;155(5):891-900.
Interpreting head CT scans. Marcus A, Marcus H, Kirollos R. Students BMJ 2013; 21:f871
No Significant Displacement of Basal Brain Structures upon Head Movement: Kinematic MRI Morphometry Relevant to Neuroendoscopy. Horsburgh A, Kirollos RW, Massoud TF. J Neurol Surg A Cent Eur Neurosurg. 2014 Mar;75(2):98-103.
The Aqueduct of Sylvius: Applied 3T MRI Anatomy and Morphometry with Neuroendoscopic Relevance. Matys T, Horsburgh A, Kirollos RW, Massoud TF. Matys T, Horsburgh A, Kirollos RW, Massoud TF. Neurosurgery. 2013 Dec;73 Suppl Operative 2:132-40
Image guided resection of spheno-orbital skull base meningiomas with predominant intra-osseous component. Marcus HJ, Schwindack CF, Nagaraju S, Santarius T, Mannion R and Kirollos RW. Acta Neurochir (Wien). 2013 Jun;155(6):981-8.
Recovery of occulomotor nerve palsy secondary to posterior communicating artery aneurysms. Patel K, Guilfoyle MR, Bulters D, Kirollos R, Antoun NM, Higgins JNP, Kirkpatrick PJ, Trivedi R. British Journal of Neurosurgery. 2014 Aug;28(4):483-7
The pathophysiology and treatment of delayed cerebral ischaemia following subarachnoid haemorrhage. Budohoski KP, Guilfoyle M, Helmy A, Huuskonen T, Czosnyka M, Kirollos R, Menon DK, Pickard JD, Kirkpatrick PJ. Journal of Neurology, Neurosurgery and Psychiatry. 2014 May 20
Alternative cost-effective method to record 3D intra-operative images: A technical note. Barone DG, Ban VS, Kirollos RW, Trivedi RA, Bulters DO, Ribas GC, Santarius T. British Journal of Neurosurgery 2014 Jun 27:1-2.
Neurosurgical Endoscopic Training via a Realistic 3-Dimensional Model With Pathology. Waran V, Narayanan V, Karuppiah R, Thambynayagam HC, Muthusamy KA, Rahman ZA, Kirollos RW. Simul Healthc. 2015 Feb;10(1):43-8.
Surgical Disconnection of the Cortical Venous Reflux for High-Grade Intracranial Dural Arteriovenous Fistulas. Al-Mahfoudh R, Kirollos R, Mitchell P, Lee M, Nahser H, Javadpour M. World Neurosurg. 2015 Apr;83(4):652-6.
No 5-ALA fluorescence seen in a recurrent papillary tumour of the pineal region (PTPR). Sun IS, Kirollos R, Santarius T. Acta Neurochir (Wien). 2015 Feb;157(2):215-6.
Pharmacological management of subarachnoid hemorrhage. Young AM, Karri SK, Helmy A, Budohoski KP, Kirollos RW, Bulters DO, Kirkpatrick PJ, Ogilvy CS, Trivedi RA.World Neurosurg. 2015 Jul;84(1):28-35.
David Price: Neurosurgeon, teacher and pioneer of digital intracranial monitoring. Czosnyka M, Kirollos RW, van Hille PT. British Journal of Neurosurgery 2015 Jun;29(3):312-3.
Bicoronal frontobasal approach with a limited, midline orbital bar osteotomy –a technical note. Patel K, Kolias AG, Kirollos RW. British Journal of Neurosurgery, 2016 Feb;30(1):104-5.
Outcome of microsurgical excision of unruptured brain arteriovenous malformations in ARUBA-eligible patients. Javadpour M, Al Mahfoudh R, Mitchell PS, Kirollos R. British Journal of Neurosurgery 2016 Dec;30(6):619-622.
The impact of major trauma centre implementation on the pathways and outcome of traumatic intracranial extradural haematoma in a regional centre. Moon RDC, Mutwakil A, Kolias AG, Krunal P, Kirollos R, Hutchinson P, Timofeev I. British Journal of Neurosurgery. 2016 May 24:1-4.
A quest towards personalised medicine for grade II meningiomas: will need to zoom in. Editorial. Santarius T, Kirollos RW, Jenkinson MD. Acta Neurochirurgica (Wien). 2016 May;158(5):931-2.
Body mass index and the risk of post-operative cerebrospinal fluid leak following transsphenoidal surgery in an Asian population. Sun I, Lim JX, Goh CP, Low SW, Kirollos R, Tan CS, Lwin S, Chou N, Yeo TT. Singapore Medical Journal. Singapore Med J. 2016 Sep 22.
Concomitant primary CNS lymphoma and FSH-pituitary adenoma arising within the sella. Entirely coincidental? Ban VS, Chaudhary BR, Allinson K, Santarius T, Kirollos RW. Neurosurgery 2017 Jan 1;80(1): E170-E175.
Clinical experience and results of microsurgical resection of arteriovenous malformation in the presence of space-occupying intracerebral hematoma. Barone DG, Marcus HJ, Guilfoyle MR, Higgins JNP, Antoun N, Santarius T, Trivedi RA, Kirollos RW. Neurosurgery 2017 Jul 1;81(1):75-86.
Volumetric growth rates of meningioma and its correlation with histological diagnosis and clinical outcome: a systematic review. Fountain DM, Soon WC, Matys T, Guilfoyle MR, Kirollos R, Santarius T. Acta Neurochir (Wien). 2017 Mar;159(3):435-445.
The Effect of 3-Dimensional Simulation on Neurosurgical Skill Acquisition and Surgical Performance: A Review of the Literature. Clark AD, Barone DG, Candy N, Guilfoyle M, Budohoski K, Hofmann R, Santarius T, Kirollos R, Trivedi RA. Journal of Surgical Education J Surg Educ. 2017 Sep - Oct;74(5):828-836.
Tablets at the bedside - iPad-based visual field test used in the diagnosis of Intrasellar Haemangiopericytoma: a case report. Nesaratnam N, Thomas PBM, Kirollos R, Vingrys AJ, Kong GYX, Martin KR. BMC Ophthalmol. 2017 Apr 24;17(1):53.
Results of transcranial resection of olfactory groove meningiomas in relation to imaging-based case selection criteria for the endoscopic approach. Patel K, Kolias AG, Santarius T, Mannion R, Kirollos RW. In press, Operative Neurosurgery.
Correlation of Volumetric Growth and Histological Grade in 50 Meningiomas. Soon WC, Fountain DM, Koczyk K, Abdulla M, Giri S, Allinson K, Matys T, Guilfoyle MR, Kirollos RW, Santarius T. Acta Neurochir (Wien). 2017 Nov;159(11):2169-2177.
Methodological shortcomings in the literature evaluating the role and applications of 3D training for surgical trainees. Kostusiak M, Hart M, Barone DG, Hofmann R, Kirollos R, Santarius T, Trivedi R. Journal: Medical Teacher (IMTE) Med Teach. 2017 Nov;39(11):1168-1173.
An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures. Collord G, Tarpey P, Kurbatova N, Martincorena I, Moran S, Castro M, Nagy T, Bignell G, Maura F, Berna J, Tubio JM, McMurran CE, Young AMH, Young MD, Noorani I, Price SJ, Watts C, Leipnitz E, Kirsch M, Schackert G, Pearson D, Devadass A, Zvi Ram, Collins VP, Allinson K, Jenkinson M, Zakaria R, Syed K, Hanemann CO, Dunn, McDermott JM, Kirollos R, Vassiliou GS, Esteller M, Behjati S, Brazma A, Santarius T, McDermott U. Submitted to Nature Genetics.
Remodeling of the feeding arterial system after surgery for resection of brain arteriovenous malformations. An observational study. Morgan MK, Guilfoyle M, Kirollos R, Heller GZ. Neurosurgery. 2018 Mar 12.
Intradural Spinal Arteriovenous Malformation of the Conus Medullaris—Management Strategies and Surgical Nuances: 3-Dimensional Video. Budohoski KP, Patel K, Guilfoyle MR, Barone DG, Sethi M, Kirollos RW, Higgins NJ, Santarius T, Trivedi RA. Operative Neurosurgery (Hagerstown). 2017 Sep 15.
Radical, Staged Approach to Extensive Posterior Fossa Pediatric Ependymoma: 3-Dimensional Operative Video. Budohoski KP, Guilfoyle MR, Barone DG, Kirollos RW, Trivedi RA, Santarius T. Operative Neurosurgery (Hagerstown). 2017 Sep 29.
Stereoscopic Three-Dimensional Neuroanatomy Lectures Enhance Neurosurgical Training: Prospective Comparison to Traditional Teaching. Clark AD, Guilfoyle MR, Candy NG, Budohoski KP, Hofmann R, Barone DG, Santarius T, Kirollos RW, Trivedi RA. World Neurosurgery 2017 Dec;108:917-923.
Antero-lateral approach for central thoracic disc prolapse - surgical strategies used to tackle differing operative findings: 3-dimensional operative video. Patel K, Budohoski KP, Kenyon ORP, Barone DG, Santarius T, Kirollos RW, Mannion RJ, Trivedi RA. Operative Neurosurgery Oper Neurosurg (Hagerstown). 2018 Apr 2.
Type I Spinal Dural Fistula treated using a minimally invasive approach with a 20mm non-expandable tubular retractor - 3 dimensional operative video. Patel K, McMillen J, Kirollos RW, Budohoski KP, Santarius T, Trivedi RA. Operative Neurosurgery Oper Neurosurg (Hagerstown). 2018 Mar 8.
Microsurgical Clipping of an Ophthalmic Artery Aneurysm With a Limited Intradural Anterior Clinoidectomy: 3-Dimensional Operative Video. Patel K, Kirollos RW, Kenyon O, Santarius T, Kirkpatrick PJ, Trivedi RA. Operative Neurosurgery (Hagerstown). 2018 Mar 3.
Predictors of early progression of surgically treated atypical meningiomas. Budohoski KP, Clerkin J, Millward C, O'Halloran P, Waqar M, Looby S, Young A, Guilfoyle M, Fitzrol D, Devadass A, Allinson K, Farrell M, Javadpour M, Jenkinson M, Santarius T, Kirollos R. In press Acta Neurochirurgica.