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Dr Yeo Crystal Jing Jing

MB BChir (Distinction, Cambridge), PhD (Cambridge), MRCP (UK), ABPN Board Cert (Neurology, Neuromuscular Medicine), ABEM Board Cert (Electrodiagnostic Medicine, Neuromuscular Ultrasound)

Consultant

National Neuroscience Institute

Specialty: Neurology

Clinical Interest: General Neurology, Neuromuscular Medicine, Electrodiagnostic Medicine, Neuromuscular Ultrasound

Conditions Treated by this Doctor:
Carpal Tunnel Syndrome, Motor Neuron Disease, Muscular Dystrophy, Myasthenia Gravis, Neuromuscular Diseases, Peripheral Neuropathy.

Clinical Appointments

Consultant Department of Neurology National Neuroscience Institute

Profile

Dr Crystal Jing Jing Yeo is a Diplomate of the American Board of Psychiatry and Neurology (Board Certified in Neurology and Neuromuscular Medicine), and American Board of Electrodiagnostic Medicine (Board Certified in Electrodiagnostic Medicine and Neuromuscular Ultrasound). She specialises in the care of patients with Neuromuscular diseases, and in nerve conductions, electromyography (NCS/EMG) and neuromuscular ultrasound.

She graduated from the University of Cambridge MB/PhD programme with Distinction in Medicine, PhD in Immunology and Honours for top performance, including The Lewin Prize, Balfour Prize and Caroline Turle Prize. She completed her Neurology residency at Weil Cornell Medicine/Houston Methodist Hospital, and Neuromuscular fellowship at Harvard University/Massachusetts General Hospital, Brigham and Women’s Hospital and Boston Children’s Hospital. She is Adjunct Associate Professor in Neurology (Neuromuscular Disease) at the Feinberg School of Medicine, Northwestern University, Honorary Senior Lecturer at the School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Newnham Associate at the University of Cambridge, Associate Staff at Boston Children’s Hospital, and directs the Translational Neuromuscular Medicine Laboratory at A*STAR.

Dr Yeo is also alumnus of the American Academy of Neurology (AAN) Palatucci Advocacy Leadership Forum, AAN Live Well Lead Well Leadership Program, Harvard Women in Leadership Course, and serves on the AAN Education Pipeline Subcommittee. She has been invited to give talks and interviews to the American Association of Neuromuscular and Electrodiagnostic Medicine, American Neurological Association, AAN, ACGME, US Women Neurologists Group, and local and international universities. She is involved in lecturing medical and graduate students at the Lee Kong Chian School of Medicine and National University of Singapore.

Education

American Board of Electrodiagnostic Medicine (Board Certified in Neuromuscular Ultrasound, 2022)
American Board of Electrodiagnostic Medicine (Board Certified in Electrodiagnostic Medicine), 2020
American Board of Psychiatry and Neurology (Board Certified in Neuromuscular Medicine), 2020
Harvard/Partners Neuromuscular Medicine Fellowship at Harvard University, Massachusetts General Hospital, Brigham and Women’s Hospital, Boston Children’s Hospital, 2018-2019
American Board of Psychiatry and Neurology (Board Certified in Neurology), 2018
Weill-Cornell Medicine/Houston Methodist Hospital Neurology Residency, 2014-2018
MRCP (United Kingdom), 2013
MB BChir (University of Cambridge, Distinction), PhD (University of Cambridge), 2011

Professional Appointments and Committee Memberships

Consultant, Department of Neurology, National Neuroscience Institute, 2022 - present
Adjunct Associate Professor of Neurology (Neuromuscular Disease), Feinberg School of Medicine, Northwestern University, 2021 - present
Honorary Senior Lecturer, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, 2020 - present
Joint Medical Director of the Experimental Drug Development Center, 2019-2021
Group leader of Translational Neuromuscular Medicine Laboratory, 2019 - present

Awards

A*STAR CDA Grant, 2020
American Academy of Neurology (AAN) Live Well Lead Well Leadership Programme, 2019
AAN Fellow Scholarship to the AAN Annual Conference, 2019
AAN Palatucci Advocacy Leadership Forum Action Plan Support Grant, 2018
Harvard/Partners Healthcare Center of Expertise Health Policy and Management Grant for the Harvard Business School Healthcare Conference, 2018
AAN Palatucci Advocacy Leadership Forum, 2018
AAN Brainstorm Competition – Grand Finals, 2018
Grifols CIDP Ambassador Programme, 2018
International Neuroethics Society Essay Competition Editorial Mentorship, 2017
9th Annual American Neurological Association Translational and Clinical Research Course Award, 2017
American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) Resident and Fellowship Abstract Award, 2017
AANEM Foundation for Research and Education Resident and Fellow Member Recognition Award, 2017
MDS-PAS Movement Disorders School Award, 2017
Cleveland Clinic 5th Annual Comprehensive Neurotoxin Course Travel Award, 2016
Distinction in MB BChir, University of Cambridge, 2011
The Lewin Prize, University of Cambridge, 2011
Caroline Turle Prize, University of Cambridge, 2011
Balfour Prize, University of Cambridge, 2011
Distinction in Pathology, University of Cambridge, 2010
PhD in Medicine, University of Cambridge, 2010
Cow and Gate Prize for Pediatrics, University of Cambridge, 2010
Commendation for Outstanding Performance in Pediatrics, University of Cambridge, 2010
Boyd-Martin Award, University of Cambridge, 2010
William Harvey Studentship Award in Clinical Medicine, University of Cambridge, 2006
Robert Lin Memorial Medal for Pharmacology, 2005
2nd Professional Exam MBBS Part 2: Dean’s List, 2005
A*STAR Roll of Honor, 2005
2nd Professional Exam MBBS Part 1: Dean’s List, 2004
First Professional Exam MBBS: Dean’s List, 2003
Singapore Medical Association Ethics Essay Competition: 1st Prize, 2002
A*STAR MBBS-PhD Scholarship Award, 2002
Raffles Junior College Award for Academic Excellence, 2001
Stanford Book Prize, 2001
Edusave EAGLES Award for Achievement, Good Leadership and Servic, 2001
Lee Kuan Yew Award for Excellence in Mathematics and Science, 2001
Raffles Top Scholar Award for Top GCE O Level 11 Distinctions, 1999
RGS Award for Excellence in Chemistry and Music, 1999

Research Interests

Amyotrophic Lateral Sclerosis (ALS)
Spinal Muscular Atrophy (SMA)
Inflammatory muscle diseases
Muscular dystrophy
Sarcopenia
Neuromuscular diseases

Publications

Yeo CJJ, Tizzano EF, Darras BT. Challenges and opportunities in spinal muscular atrophy therapeutics. Lancet Neurol. 2024 Feb;23(2):205-218. doi: 10.1016/S1474-4422(23)00419-2. PMID: 38267192.
Din Abdul Jabbar MA, Guo L, Guo Y, Simmons Z, Pioro EP, Ramasamy S, Yeo CJJ*. Predicting amyotrophic lateral sclerosis (ALS) progression with machine learning, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2023 Dec DOI: 10.1080/21678421.2023.2285443
Din Abdul Jabbar MA, Guo L, Guo Y, Simmons Z, Pioro EP, Ramasamy S, Yeo CJJ*. Describing and characterising variability in ALS disease progression. Amyotroph Lateral Scler Frontotemporal Degener. 2023 Oct 5:1-12. PMID: 37794802.
Yeo CJJ, Darras BT. Translating fatigability in spinal muscular atrophy to clinical trials and management. Muscle Nerve. 2023 Jul;68(1):6-7. doi: 10.1002/mus.27831. Epub 2023 Apr 22. PMID: 37086214; PMCID: PMC10334865.
Yeo CJJ, Dastgir J, Darras BT. Neonatal Hypotonia and Neuromuscular Disorders. Perlman J, Neurology: Neonatology Questions and Controversies, 4e, Chapter 13, 213-236
Huber RG, Pandey S, Chhangani D, Rincon-Limas DE, Staff NP, Yeo CJJ*. Identification of potential pathways and biomarkers linked to progression in ALS. Ann Clin Transl Neurol. 2022 Dec 19. doi: 10.1002/acn3.51697.
Ong WY, Leow DM, Herr DR, Yeo CJ. What Do Randomized Controlled Trials Inform Us About Potential Disease- Modifying Strategies for Parkinson's Disease? Neuromolecular Med. 2022 Jul 1. doi: 10.1007/s12017-022-08718-x. PMID: 35776238
Crystal Jing Jing Yeo, Alexis Levine, Basil Darras. Hepatic Steatosis in Patients with Spinal Muscular Atrophy (SMA). Neurology May 2022, 98 (18 Supplement) 2692
Muzammil Arif Din Abdul Jabbar, Guo Yang, Erik Pioro, Savitha Ramasamy, Crystal Jing Jing Yeo*. Implications and Predictors of Variability of Disease Progression in Amyotrophic Lateral Sclerosis (ALS). Neurology May 2022, 98 (18 Supplement) 1873
Muzammil Arif Din Abdul Jabbar, Guo Yang, Erik Pioro, Savitha Ramasamy, Crystal Jing Jing Yeo*. Predicting Fast Progressors in Amyotrophic Lateral Sclerosis (ALS): A Machine Learning Approach. Neurology May 2022, 98 (18 Supplement) 1891
Roland Huber, Crystal Jing Jing Yeo*. Fast Progression in Amyotrophic Lateral Sclerosis: Pathways and Biomarkers from Multi-Omics Analysis. Neurology May 2022, 98 (18 Supplement) 696
Yeo CJJ, Simmons Z, De Vivo DC, Darras BT. Reply to: The 4-Copy Conundrum in the Treatment of Infants with Spinal Muscular Atrophy. Ann Neurol. 2022 Jun;91(6):892. doi: 10.1002/ana.26357. Epub 2022 Apr 9. PMID: 35332578
Yeo CJJ, Simmons Z, De Vivo DC, Darras BT. Ethical Perspectives on Treatment Options with Spinal Muscular Atrophy Patients. Ann Neurol. 2022 Mar;91(3):305-316. doi: 10.1002/ana.26299. Epub 2022 Jan 25. PMID: 34981567.
Yeo CJJ, Darras BT. A tale of two diseases: spinal muscular atrophy and Pompe disease. Lancet Child Adolesc Health. 2022 Jan;6(1):2-3. doi: 10.1016/S2352-4642(21)00351-5. Epub 2021 Nov 22. PMID: 34822770.
Yeo, C.J.J. and Darras, B.T. Hepatic Steatosis in Patients with Spinal Muscular Atrophy. Ann Neurol. 2021 Oct, Volume 90, Issue S27.
Yeo CJJ and Darras BT. Overview of Spinal Muscular Atrophy for the Child Neurology Foundation. June 2021
Yeo, C.J.J. and Darras, B.T. (2020), Yeo and Darras: Extraneuronal Phenotypes of Spinal Muscular Atrophy. Ann Neurol. 2020 Oct 13. doi: 10.1002/ana.25930. https://doi.org/10.1002/ana.25930
Angkodjojo S, Yeo CJJ. A Patient with Limbic Encephalitis, Ear Perichondritis, and Episcleritis – An Unusual Presentation of Relapsing Polychondritis. Case Rep Neurol 2020;12:378-386. doi: 10.1159/000510634
Yeo CJJ, Simeone SD, Townsend EL, Zhang RZ, Swoboda KJ. Prospective Cohort Study of Nusinersen Treatment in Adults with Spinal Muscular Atrophy. J Neuromuscul Dis. 2020;7(3):257-268. doi: 10.3233/JND-190453.
Yeo CJJ, Darras BT. Overturning the Paradigm of Spinal Muscular Atrophy as just a Motor Neuron Disease. Pediatr Neurol. 2020;S0887-8994(20)30027-8. doi:10.1016/j.pediatrneurol.2020.01.003
Yeo CJ, Schwarz H, O’Donovan C, Busis N, Deb A, Wiesman J, Powell S, Molano J. Providing an easily accessible online resource for physician wellness advocates (2358). Neurology Apr 2020, 94 (15 Supplement) 2358
Yeo CJ, Ng SY, Darras BT. Reduced Spinal Motor Neuron Expression of Insulin-like Growth Factor-2 and Insulinlike Growth Factor Binding Protein 5 in Spinal Muscular Atrophy Type 1 (1262). Neurology Apr 2020, 94 (15 Supplement) 1262
Yeo CJ, Simeone S, Zhang RZ, Trautman K, Damron B, Nwe P, Siranosian J, Johnstone A, Chen JY, Townsend E, Nery F, Herrmann M, Swoboda K. Outcome measures for Nusinersen efficacy in Adults with Spinal Muscular Atrophy. Neurology Apr 2019, 92 (15 Supplement) S5.008
Yeo CJ, Babieri A, Roman G, Wiesman J, Powell SZ. Using Smartphone Mindfulness Apps to Increase Trainee Resilience and Reduce Burnout. Neurology Apr 2019, 92 (15 Supplement) P2.9-005
Yeo CJ et al. Scrubber’s Radial Palsy - Proximal Compression of the Radial Nerve at the Origin of the Brachioradialis. Neurology Apr 2019, 92 (15 Supplement) P4.4-037
Yeo CJJ. Haiku on Phone. Closler, Johns Hopkins Medicine June 2019
Yeo CJJ. Bringing compassion, resiliency and humanity to medicine. Brigham and Women’s Hospital Clinical and Research News Jan 2019
Yeo CJJ, Román GC, Kusnerik D, Burt T, Mersinger D, Thomas S, Boone T, Powell SZ. Trainee Responses to Hurricane Harvey: Correlating Volunteerism With Burnout. Front Public Health. 2018; 6:224.
Yeo CJJ. Right Brain: Should we wear flowers in our hair? Neurology Oct 2018, 91 (16) 761; DOI: 10.1212/WNL.0000000000006364
Yeo CJJ. Neurology, May 16, 2018 e-Pearl of the Week: Antiphospholipid antibody-associated chorea. http://n.neurology.org/epearls/20180516
Yeo CJJ, Hutton GJ, Fung SH. Advanced neuroimaging in Balo's concentric sclerosis: MRI, MRS, DTI, and ASL perfusion imaging over 1 year. Radiol Case Rep. 2018 Oct; 13(5):1030-1035.
Yeo CJ, Ondo W. Tremor Research Group Essential Tremor Rating Scale (TETRAS): Assessing Impact of Different Item Instructions. Neurology Apr 2018, 90 (15 Supplement) P6.062
Yeo CJJ and Pleitez M. Eculizumab in Refractory Myasthenia Crisis. Muscle Nerve. 2018 Aug; 58(2):E13-E15.
Yeo CJJ and Simmons Z. Discussing edaravone with the ALS patient: an ethical framework from a U.S. perspective, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2018, 19:3-4, 167-172
Yeo CJJ, Britz G, Powell, S, Smith, R & Zhang, Yi. Recurrent Cerebral Hemorrhages in Normal Pregnancy Secondary to Mycotic Pseudoaneurysms Related to Choriocarcinoma. World Neurosurg. 2018 Jan; 109:247- 250.
Yeo CJ, Bunin V, Popovich J, Cykowski M, Smith R. Mitochondrial Skeletal and Cardiac Myopathy Responsive to Aggressive Immunosuppression in Rapidly Progressing Systemic Sclerosis. Neurology Apr 2017, 88 (16 Supplement) P5.077
Yeo CJ, McCane D, Katz L, Ling K, Capetillo A, Bledsoe D, Chiu D. Variables affecting stroke outcome for t-PA received between 3 to 4.5 hours. Neurology Apr 2016, 86 (16 Supplement) P2.301
Yeo CJ, Gilman AL. Interleukin-2-induced graft-versus-leukemia for the treatment of AML in a BRCA2 Fanconi anemia patient. Journal of Pediatric Hematology/oncology. 2014 Mar;36(2):e78-80.
Yeo CJJ, Fearon DT. T-bet-mediated differentiation of the activated CD8+ T cell. European Journal of Immunology. 2011 Jan; 41(1):60-66.
Yeo CJJ. Ethical dilemmas of the practice of medicine in the information technology age. Singapore Med J 2003; 44:141-4.