Zhang ZW, Tu H, Jiang M, Vanan S, Chia SY, Jang SE, Saw WT, Ong ZW, Ma DR, Zhou ZD, Xu J, Guo KH, Yu WP, Ling SC, Margolin RA, Chain DG, Zeng L, Tan EK. The APP intracellular domain promotes LRRK2 expression to enable feed-forward neurodegenerative mechanisms in Parkinson's disease. Sci Signal. 2022 Aug 23;15(748):eabk3411.
Deng X, Saffari SE, Ng SYE, Chia N, Tan JY, Choi X, Heng DL, Xu Z, Tay KY, Au WL, Liu N, Ng A, Tan EK, Tan LCS. Blood Lipid Biomarkers in Early Parkinson's Disease and Parkinson's Disease with Mild Cognitive Impairment. J Parkinsons Dis. 2022;12(6):1937-1943.
Tan JSY, Lee B, Lim J, Ma DR, Goh JX, Goh SY, Gulam MY, Koh SM, Lee WW, Feng L, Wang Q, Chao Y, Rötzschke O, Tan EK. Parkinson's Disease-Specific Autoantibodies against the Neuroprotective Co-Chaperone STIP1. Cells. 2022 May 16;11(10):1649.
Zhou ZD, Jankovic J, Ashizawa T, Tan EK. Neurodegenerative diseases associated with non-coding CGG tandem repeat expansions. Nat Rev Neurol. 2022 Mar;18(3):145-157.
Jo J, Yang L, Tran HD, Yu W, Sun AX, Chang YY, Jung BC, Lee SJ, Saw TY, Xiao B, Khoo ATT, Yaw LP, Xie JJ, Lokman H, Ong WY, Lim GGY, Lim KL, Tan EK, Ng HH, Je HS. Lewy-body Like Inclusions in Human Midbrain Organoid Carrying Glucocerebrosidase and Alpha Synuclein Mutations. Ann Neurol. 2021 Sep;90(3):490-505.
Toh J, Chua LL, Ho P, Sandanaraj E, Tang C, Wang H, Tan EK. Identification of Targets from LRRK2 Rescue Phenotypes. Cells. 2021 Jan 5;10(1):76.
Ma D, Tan YJ, Ng ASL, Ong HL, Sim W, Lim WK, Teo JX, Ng EYL, Lim EC, Lim EW, Chan LL, Tan LCS, Yi Z, Tan EK. Association of NOTCH2NLC Repeat Expansions with Parkinson Disease. JAMA Neurol. 2020 Dec 1;77(12):1559-1563.
Chua LL, Ho P, Toh J, Tan EK. Chetomin rescues pathogenic phenotype of LRRK2 mutation in drosophila. Aging (Albany NY). 2020 Sep 24;12(18):18561-18570.
Ng ASL, Lim WK, Xu Z, Ong HL, Tan YJ, Sim WY, Ng EYL, Teo JX, Foo JN, Lim TCC, Yu WY, Chan LL, Lee HY, Chen Z, Lim EW, Ting SKS, Prakash KM, Tan LCS, Yi Z, Tan EK. NOTCH2NLC GGC Repeat Expansions Are Associated with Sporadic Essential Tremor: Variable Disease Expressivity on Long-Term Follow-up. Ann Neurol. 2020 Sep;88(3):614-618.
Tan EK, Chao YX, West A, Chan LL, Poewe W, Jankovic J. Parkinson disease and the immune system - associations, mechanisms and therapeutics. Nat Rev Neurol. 2020 Jun;16(6):303-318.
Sun AX, Yuan Q, Fukuda M, Yu W, Yan H, Lim GGY, Nai MH, D’Agostino GA, Tran HD, Itahana Y, Wang D, Lokman H, Itahana K, Lim SWL, Tang J, Chang YY, Zhang M, Cook SA, Rackman OJL, Lim CT, Tan EK, Ng HH, Lim KL, Jiang YH, Je HS. Potassium channel dysfunction in human neuronal models of Angelman syndrome. Science. 2019 Dec 20;366(6472):1486-1492.
*Xiao B, Deng X, Ng EY, Allen JC Jr, Lim SY, Ahmad-Annuar A, Tan EK. Association of LRRK2 Haplotype with Age at Onset in Parkinson Disease. JAMA Neurol. 2018 Jan 1;75(1):127-128.
Jo J, Xiao Y, Sun AX, Cukuroglu E, Tran HD, Göke J, Tan ZY, Saw TY, Tan CP, Lokman H, Lee Y, Kim D, Ko HS, Kim SO, Park JH, Cho NJ, Hyde TM, Kleinman JE, Shin JH, Weinberger DR, Tan EK#, Je HS#, Ng HH#. Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons. Cell Stem Cell 2016 Aug 4;19(2):248-57. #Joint senior author
Tan EK, et al. Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus. Neurology 2010 Aug 10;75(6):508-12.
Tan EK, Ho P, Tan L, Prakash KM, Zhao Y. PLA2G6 mutations and Parkinson’s disease. Ann Neurol 2010 Jan;67(1):148.